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Article

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.

Current biology : CB - 26 Jul 2005

Dimitri Christopher A, Dowdle William, MacKeigan Jeffrey P, Blenis John, Murphy Leon O

Abstract excerpt

Inhibitors of the oncogenic Ras-MAPK pathway have been intensely pursued as therapeutics. Targeting this pathway, however, presents challenges due to the essential role of MAPK in homeostatic functions. The phosphorylation and activation of MAPK substrates is regulated by protein-protein interactions with MAPK docking sites. Active ERK1/2 (extracellular signal-regulated kinase 1/2)-MAPKs localize to effectors...

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Identifiers

PMID: 16051177
DOI: 10.1016/j.cub.2005.06.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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