Article
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events.
Molecular cell - 9 Apr 2010
Shin Sejeong, Dimitri Christopher A, Yoon Sang-Oh, Dowdle William, Blenis John
Abstract excerpt
Hyperactivation of Ras-ERK1/2 signaling is critical to the development of many human malignancies, but little is known regarding the specific contribution of ERK1 or ERK2 to oncogenic processes. We demonstrate that ERK2 but not ERK1 signaling is necessary for Ras-induced epithelial-to-mesenchymal transformation (EMT). Further, ERK2 but not ERK1 overexpression is sufficient to induce EMT. Many ERK1/2-interacting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.