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Article

Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity.

The Journal of biological chemistry - 28 Jan 2011

Burkhard Kimberly A, Chen Fengming, Shapiro Paul

Abstract excerpt

Extracellular signal-regulated kinase-1 and -2 (ERK1/2) proteins regulate a variety of cellular functions, including cell proliferation and differentiation, by interacting with and phosphorylating substrate proteins. Two docking sites, common docking (CD/ED) domain and F-site recruitment site (FRS), on ERK proteins have been identified. Specific interactions with the CD/ED domain and the FRS occur with substrates...

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Identifiers

PMID: 21098038
DOI: 10.1074/jbc.M110.177899
PMCID: PMC3024742

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