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Article

Deciphering the RAS/ERK pathway in vivo.

Biochemical Society transactions - 8 Feb 2017

Dorard Coralie, Vucak Georg, Baccarini Manuela

Abstract excerpt

The RAS/ERK pathway has been intensely studied for about three decades, not least because of its role in human pathologies. ERK activation is observed in the majority of human cancers; in about one-third of them, it is driven by mutational activation of pathway components. The pathway is arguably one of the best targets for molecule-based pharmacological intervention, and several small-molecule inhibitors are in...

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Identifiers

PMID: 28202657
DOI: 10.1042/BST20160135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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