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Article

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.

Cellular signalling - 1 Jan 2006

Grewal S, Molina D M, Bardwell L

Abstract excerpt

Docking sites on targets of mitogen-activated protein kinases (MAPKs) facilitate accurate and efficient substrate phosphorylation. MAPK/ERK kinases (MEKs, or MKKs), the upstream regulators of MAPKs, also contain N-terminal MAPK-docking sites, or 'D-sites'; however, the in vivo functions of MEK D-sites are incompletely understood. Here we found that the ability of constitutively-active human MEK1 and MEK2 to...

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Identifiers

PMID: 15979847
DOI: 10.1016/j.cellsig.2005.04.001
PMCID: PMC3017502

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