Article
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase.
Genes & development - 15 Jan 1999
Jacobs D, Glossip D, Xing H, Muslin A J, Kornfeld K
Abstract excerpt
MAP kinases phosphorylate specific groups of substrate proteins. Here we show that the amino acid sequence FXFP is an evolutionarily conserved docking site that mediates ERK MAP kinase binding to substrates in multiple protein families. FXFP and the D box, a different docking site, form a modular recognition system, as they can function independently or in combination. FXFP is specific for ERK, whereas the D box...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Binding Sites
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Conserved Sequence
- Enzyme Inhibitors
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- Mice
- Mitogen-Activated Protein Kinase 1