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Article

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase.

Genes & development - 15 Jan 1999

Jacobs D, Glossip D, Xing H, Muslin A J, Kornfeld K

Abstract excerpt

MAP kinases phosphorylate specific groups of substrate proteins. Here we show that the amino acid sequence FXFP is an evolutionarily conserved docking site that mediates ERK MAP kinase binding to substrates in multiple protein families. FXFP and the D box, a different docking site, form a modular recognition system, as they can function independently or in combination. FXFP is specific for ERK, whereas the D box...

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PMID: 9925641
PMCID: PMC316390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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