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Article

Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.

The Journal of biological chemistry - 7 Mar 2008

Caunt Christopher J, Rivers Caroline A, Conway-Campbell Becky L, Norman Michael R, McArdle Craig A

Abstract excerpt

Spatiotemporal aspects of ERK activation are stimulus-specific and dictate cellular consequences. They are dependent upon dual specificity phosphatases (DUSPs) that bind ERK via docking domains and can both inactivate and anchor ERK in cellular compartments. Using high throughput fluorescence microscopy in combination with a system where endogenous ERKs are removed and replaced with wild-type or mutated...

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Identifiers

PMID: 18178562
DOI: 10.1074/jbc.M706624200
PMCID: PMC2268109

Genes

DUSP1
DUSP2
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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