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Article

A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates.

The Journal of biological chemistry - 8 Aug 2003

Zhang Jialin, Zhou Bo, Zheng Chao-feng, Zhang Zhong-yin

Abstract excerpt

Mitogen-activated protein (MAP) kinases control gene expression in response to extracellular stimuli and exhibit exquisite specificity for their cognate regulators and substrates. We performed a structure-based mutational analysis of ERK2 to identify surface areas that are important for recognition of its interacting proteins. We show that binding and activation of MKP3 by ERK2 involve two distinct...

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Identifiers

PMID: 12754209
DOI: 10.1074/jbc.M303909200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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