Article
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.
The Journal of physiology - 1 Feb 1999
Sanguinetti M C, Xu Q P
Abstract excerpt
1. The structural basis for the activation gate of voltage-dependent K+ channels is not known, but indirect evidence has implicated the S4-S5 linker, the cytoplasmic region between the fourth and fifth transmembrane domains of the channel subunit. We have studied the effects of mutations in the S...
Topics
- Animals
- Biotransformation
- Cation Transport Proteins
- Cytoplasm
- DNA-Binding Proteins
- ERG1 Potassium Channel
- Electric Stimulation
- Electrophysiology
- Ether-A-Go-Go Potassium Channels
- Humans
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Mutagenesis, Insertional
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Potassium Channels