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Article

Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.

Biophysical journal - 24 Jan 2017

Thouta Samrat, Hull Christina M, Shi Yu Patrick, Sergeev Valentine, Young James, Cheng Yen M, Claydon Thomas W

Abstract excerpt

Slow deactivation of hERG channels is critical for preventing cardiac arrhythmia yet the mechanistic basis for the slow gating transition is unclear. Here, we characterized the temporal sequence of events leading to voltage sensor stabilization upon membrane depolarization. Progressive increase in step depolarization duration slowed voltage-sensor return in a biphasic manner (τfast = 34 ms, τslow = 2.5 s). The...

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Share to Electrophysiological Phenomena
Share to Ether-A-Go-Go Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Kinetics

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Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 28122216
DOI: 10.1016/j.bpj.2016.12.021
PMCID: PMC5266146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.PMID 28122216Read ↗

Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.Semantic proximity Read ↗

Voltage sensor movement in the hERG K+ channel.Semantic proximity Read ↗

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.Semantic proximity Read ↗

Fast and slow voltage sensor movements in HERG potassium channels.Semantic proximity Read ↗

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.Semantic proximity Read ↗

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.Semantic proximity Read ↗

Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.Semantic proximity Read ↗

Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Semantic proximity Read ↗

Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Semantic proximity Read ↗

S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel.Semantic proximity Read ↗

Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium ChannelsSemantic proximity Read ↗

Molecular determinants of U-type inactivation in Kv2.1 channels.Semantic proximity Read ↗

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