Article
Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.
Oncogene - 10 Apr 2003
Laiho Päivi, Hienonen Tuija, Karhu Auli, Lipton Lara, Aalto Yan, Thomas Huw J W, Birkenkamp-Demtroder Karin, Hodgson Shirley, Salovaara Reijo, Mecklin Jukka-Pekka, Järvinen Heikki, Knuutila Sakari, Halford Sarah, Ørntoft Torben F, Tomlinson Ian, Launonen Virpi, Houlston Richard, Aaltonen Lauri A
Abstract excerpt
We have allelotyped a series of 104 Finnish colorectal cancers (CRCs) using 372 polymorphic markers spaced, on average, at 10 cM intervals, and have made a comparison of the differences in the frequency of allelic imbalance (AI) between familial and sporadic cases. Differences in the frequency of allelic imbalance (loss of heterozygosity or amplification) at a number of loci were detected and these were evaluated...
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