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Article

Activity-dependent polyadenylation in neurons

25 Jul 2005

Abstract excerpt

Activity-dependent changes in protein synthesis modify synaptic efficacy. One mechanism that regulates mRNA translation in the synapto-dendritic compartment is cytoplasmic polyadenylation, a process controlled by CPEB, the cytoplasmic polyadenylation element (CPE)-specific RNA binding protein. In neurons, very few mRNAs are known CPEB substrates, and none appear to be responsible for the effects on plasticity...

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PMID: 16043499
DOI: 10.1261/rna.2870505

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