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Article

Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation.

The Biochemical journal - 1 Jul 2012

Friend Kyle, Brook Matthew, Bezirci F Betül, Sheets Michael D, Gray Nicola K, Seli Emre

Abstract excerpt

Oocyte maturation and early embryonic development require the cytoplasmic polyadenylation and concomitant translational activation of stored maternal mRNAs. ePAB [embryonic poly(A)-binding protein, also known as ePABP and PABPc1-like] is a multifunctional post-transcriptional regulator that binds to poly(A) tails. In the present study we find that ePAB is a dynamically modified phosphoprotein in Xenopus laevis...

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Identifiers

PMID: 22497250
DOI: 10.1042/BJ20120304
PMCID: PMC3955212

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Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation.PMID 22497250Read ↗

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The 36-kilodalton embryonic-type cytoplasmic polyadenylation element-binding protein in Xenopus laevis is ElrA, a member of the ELAV family of RNA-binding proteins.Semantic proximity Read ↗

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