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Article

Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.

Genes & development - 15 Nov 2015

Chen Fei, Zhou Yu, Qi Yingchuan B, Khivansara Vishal, Li Hairi, Chun Sang Young, Kim John K, Fu Xiang-Dong, Jin Yishi

Abstract excerpt

Alternative polyadenylation (APA) is widespread in neuronal development and activity-mediated neural plasticity. However, the underlying molecular mechanisms are largely unknown. We used systematic genetic studies and genome-wide surveys of the transcriptional landscape to identify a context-dependent regulatory pathway controlling APA in the Caenorhabditis elegans nervous system. Loss of function in ssup-72, a...

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Identifiers

PMID: 26588990
DOI: 10.1101/gad.266650.115
PMCID: PMC4691892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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