Article

Large-scale changes to mRNA polyadenylation in temporal lobe epilepsy

2019-08-08

Abstract excerpt

The molecular mechanisms that shape the gene expression landscape during the development and maintenance of chronic states of brain hyperexcitability are incompletely understood. Here we show that cytoplasmic mRNA polyadenylation, a posttranscriptional mechanism for regulating gene expression, undergoes widespread reorganisation in temporal lobe epilepsy. Specifically, over 25% of the hippocampal transcriptome dis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fd36479-39fb-5658-9229-55462e611395
DOI: 10.1101/725325

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale changes to mRNA polyadenylation in temporal lobe epilepsyDOI 10.1101/725325Read

Isoform-specific regulation of rhythmic gene expression by alternative polyadenylationSemantic proximity Read

Activity-dependent polyadenylation in neuronsSemantic proximity Read

N6-methyladenosine (m6A) dysregulation contributes to network excitability in temporal lobe epilepsySemantic proximity Read

Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1Semantic proximity Read

Transcriptome analysis reveals higher levels of mobile element-associated abnormal gene transcripts in temporal lobe epilepsy patientsSemantic proximity Read

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disordersSemantic proximity Read

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.Semantic proximity Read

TREND-DB – A Transcriptome-wide Atlas of the Dynamic Landscape of Alternative PolyadenylationSemantic proximity Read

Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastomaSemantic proximity Read

Re-polyadenylation occurs predominantly on maternal mRNA degradation intermediates during mammalian oocyte-to-embryo transitionSemantic proximity Read

Implications of Poly(A) Tail Processing in Repeat Expansion DiseasesSemantic proximity Read

Single-cell alternative polyadenylation analysis reveals mechanistic insights of COVID-19-associated neurological and psychiatric effectsSemantic proximity Read