Article

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

2023-06-09

Abstract excerpt

A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element binding protein 3 ( CPEB3 ) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the activity of the murine sequence and found that the ribozyme’s self-scission half-life matches the time it takes an RNA polymerase to reach the immediate downst...

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Literature Corpus work: 62f0f32b-0e84-5eb3-84c7-294191b4c111
DOI: 10.1101/2023.06.07.543953

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