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Article

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

Nature - 1 Aug 2018

Parras Alberto, Anta Héctor, Santos-Galindo María, Swarup Vivek, Elorza Ainara, Nieto-González José L, Picó Sara, Hernández Ivó H, Díaz-Hernández Juan I, Belloc Eulàlia, Rodolosse Annie, Parikshak Neelroop N, Peñagarikano Olga, Fernández-Chacón Rafael, Irimia Manuel, Navarro Pilar, Geschwind Daniel H, Méndez Raúl, Lucas José J

Abstract excerpt

Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple ASD risk genes during neurodevelopment. Cytoplasmic polyadenylation element binding proteins 1-4 (CPEB1-4) regulate the...

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Identifiers

PMID: 30111840
DOI: 10.1038/s41586-018-0423-5
PMCID: PMC6217926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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