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Article

The crystal structure of MCAT from Mycobacterium tuberculosis reveals three new catalytic models.

Journal of molecular biology - 24 Aug 2007

Li Zexuan, Huang Yishu, Ge Jing, Fan Hang, Zhou Xiaohong, Li Shentao, Bartlam Mark, Wang Honghai, Rao Zihe

Abstract excerpt

The malonyl coenzyme A (CoA)-acyl carrier protein (ACP) transacylase (MCAT) plays a key role in cell wall biosynthesis in Mycobacterium tuberculosis and other bacteria. The M. tuberculosis MCAT (MtMCAT) is encoded by the FabD gene and catalyzes the transacylation of malonate from malonyl-CoA to holo-ACP. Malonyl-ACP is the substrate in fatty acid biosynthesis and is a by-product of the transacylation reaction....

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Source

Identifiers

PMID: 17604051
DOI: 10.1016/j.jmb.2007.06.004

Genes

MCAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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