Article
Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians.
Neuroscience letters - 17 Dec 1999
Panza F, Solfrizzi V, Torres F, Mastroianni F, Del Parigi A, Colacicco A M, Basile A M, Capurso C, Noya R, Capurso A
Abstract excerpt
Apolipoprotein E (apoE) polymorphism was studied in 79 sporadic late onset Alzheimer's disease (LOAD) patients, 125 unrelated caregivers or volunteers (19-80 years), and 67 centenarians from Apulia, Southern Italy. The frequency of apoE epsilon2 allele was higher in centenarians than in LOAD patients, while epsilon4 was lower. In middle-aged adults, the epsilon4 allele frequency was higher than in centenarians....
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