Article
A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2000
Radu D L, Noben-Trauth N, Hu-Li J, Paul W E, Bona C A
Abstract excerpt
Autoimmune insulin-dependent diabetes mellitus (IDDM) occurs spontaneously in mice-bearing transgenes encoding the influenza hemagglutinin under the control of the rat insulin promoter and a T cell receptor specific for an hemagglutinin peptide associated with I-E(d). Such "double transgenic" mice expressing wild-type or targeted IL-4Ralpha genes were examined for the onset of IDDM. Eight of 11 mice homozygous...
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