Article
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
The Journal of biological chemistry - 16 Sept 2005
Opresko Patricia L, Mason Penelope A, Podell Elaine R, Lei Ming, Hickson Ian D, Cech Thomas R, Bohr Vilhelm A
Abstract excerpt
Defects in human RecQ helicases WRN and BLM are responsible for the cancer-prone disorders Werner syndrome and Bloom syndrome. Cellular phenotypes of Werner syndrome and Bloom syndrome, including genomic instability and premature senescence, are consistent with telomere dysfunction. RecQ helicases are proposed to function in dissociating alternative DNA structures during recombination and/or replication at...
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