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Article

Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration Activity

8 Oct 2009

Abstract excerpt

Loss of the RecQ DNA helicase WRN protein causes Werner syndrome, in which patients exhibit features of premature aging and increased cancer. WRN deficiency induces cellular defects in DNA replication, mitotic homologous recombination (HR), and telomere stability. In addition to DNA unwinding activity, WRN also possesses exonuclease, strand annealing, and branch migration activities. The single strand binding...

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Share to Carcinogens and Genotoxicity Assessment
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Identifiers

PMID: 19812417
DOI: 10.1074/jbc.m109.049031

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Related research

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Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration ActivityPMID 19812417Read ↗

The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and DegradationSemantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.Semantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structuresSemantic proximity Read ↗

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structuresSemantic proximity Read ↗

Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repairSemantic proximity Read ↗

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsSemantic proximity Read ↗

p53 Modulates RPA-Dependent and RPA-Independent WRN Helicase ActivitySemantic proximity Read ↗

Actin nucleators safeguard replication forks by limiting nascent strand degradationSemantic proximity Read ↗

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