Article

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990-11-01

Abstract excerpt

Mutations in the p53 gene have been associated with a wide range of human tumors, including osteosarcomas. Although it has been shown that wild-type p53 can block the ability of E1a and ras to cotransform primary rodent cells, it is poorly understood why inactivation of the p53 gene is important for tumor formation. We show that overexpression of the gene encoding wild-type p53 blocks the growth of osteosarcoma ce...

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Literature Corpus work: 243e4347-9cf4-5b9d-a869-93b887b98a79
DOI: 10.1128/mcb.10.11.5772-5781.1990

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