Article
In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants by using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.
Journal of virology - 1 Nov 2010
Koh Yasuhiro, Amano Masayuki, Towata Tomomi, Danish Matthew, Leshchenko-Yashchuk Sofiya, Das Debananda, Nakayama Maki, Tojo Yasushi, Ghosh Arun K, Mitsuya Hiroaki
Abstract excerpt
We attempted to select HIV-1 variants resistant to darunavir (DRV), which potently inhibits the enzymatic activity and dimerization of protease and has a high genetic barrier to HIV-1 development of resistance to DRV. We conducted selection using a mixture of 8 highly multi-protease inhibitor (PI)-resistant, DRV-susceptible clinical HIV-1 variants (HIV-1(MIX)) containing 9 to 14 PI resistance-associated amino...
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