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Article

Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors.

Journal of medical virology - 1 Dec 1999

Cabana M, Clotet B, Martínez M A

Abstract excerpt

The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure. Complex mutational patterns in the reverse transcriptase gene were observed. In particular, combinations of AZT...

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Identifiers

PMID: 10534730
DOI: 10.1002/(sici)1096-9071(199912)59:4<480::aid-jmv10>3.0.co;2-8

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