Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors.

doi:10.1002/(sici)1096-9071(199912)59:4<480::aid-jmv10>3.0.co;2-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors.

Journal of medical virology - 1 Dec 1999

Cabana M, Clotet B, Martínez M A

Abstract excerpt

The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failur...

Topics

Adult
Amino Acid Sequence
Base Sequence
Cohort Studies
Consensus Sequence
DNA, Complementary
Drug Resistance, Microbial
Drug Resistance, Multiple
Evolution, Molecular
Female
HIV Infections
HIV Protease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Protease Inhibitors

HIV Reverse Transcriptase

HIV-1

Humans

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 10534730
DOI: 10.1002/(sici)1096-9071(199912)59:4<480::aid-jmv10>3.0.co;2-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10534730-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors.PMID 10534730Read ↗

Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients.Semantic proximity Read ↗

Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individuals.Semantic proximity Read ↗

Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy.Semantic proximity Read ↗

Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy.Semantic proximity Read ↗

Emergence of drug resistance mutations in human immunodeficiency virus type 2-infected subjects undergoing antiretroviral therapy.Semantic proximity Read ↗

Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors.Semantic proximity Read ↗

Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients.Semantic proximity Read ↗

Transmission of antiretroviral-drug-resistant HIV-1 variants.Semantic proximity Read ↗

Analysis of HIV-1 mutation patterns in patients failing antiretroviral therapy.Semantic proximity Read ↗

A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.Semantic proximity Read ↗

In vitro study of resistance-associated genotypic mutations to nucleoside analogs.Semantic proximity Read ↗

Comparison of protease genotype and phenotype in HIV-1 infected patients exposed to more than one protease inhibitor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.