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Article

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

5 Sept 2003

Abstract excerpt

Different components of the AP1 transcription factor complex appear to have distinct effects on cell proliferation and transformation. In contrast to other AP1 components, JunD has been shown to inhibit cell proliferation. Also, in prior studies, JunD alone bound menin, product of the MEN1 tumor suppressor gene, and JunD's transcriptional activity was inhibited by menin, suggesting that JunD might achieve all or...

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PMID: 12960363
DOI: 10.1073/pnas.1834524100

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Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoterPMID 12960363Read ↗

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Transfection of the Multiple Endocrine Neoplasia Type 1 Gene to a Human Endocrine Pancreatic Tumor Cell Line Inhibits Cell Growth and Affects Expression of JunD, δ-Like Protein 1/Preadipocyte Factor-1, Proliferating Cell Nuclear Antigen, and QM/Jif-1Semantic proximity Read ↗

JunB contributes to Id2 repression and the epithelial–mesenchymal transition in response to transforming growth factor–βSemantic proximity Read ↗

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