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Article

Heparin-binding sites in granulocyte-macrophage colony-stimulating factor. Localization and regulation by histidine ionization.

The Journal of biological chemistry - 9 Sept 2005

Sebollela Adriano, Cagliari Thiago C, Limaverde Gabriel S C S, Chapeaurouge Alex, Sorgine Marcos H F, Coelho-Sampaio Tatiana, Ramos Carlos H I, Ferreira Sérgio T

Abstract excerpt

The biological activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) is modulated by the sulfated glycosaminoglycans (GAGs) heparan sulfate and heparin. However, the molecular mechanisms involved in such interactions are still not completely understood. We have proposed previously that helix C, one of the four alpha-helices of human GM-CSF (hGM-CSF), contains a GAG-binding site in which positively...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 16027123
DOI: 10.1074/jbc.M505314200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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