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Article

Analysis of two acidic P6 pocket residues in the pH dependency of peptide binding by I-E(k).

Molecular immunology - 1 Jun 2002

Dao Chinh T, Weber Dominique A, Jensen Peter E

Abstract excerpt

Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency of peptide binding. Protonation of these critical residues, under acidic conditions, has been...

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Identifiers

PMID: 12044780
DOI: 10.1016/s0161-5890(02)00010-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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