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Article

The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.

The Biochemical journal - 24 Feb 2010

Mirza Shamaruh, Walker Andrew, Chen Jinglong, Murphy James M, Young Ian G

Abstract excerpt

GM-CSF (granulocyte/macrophage colony-stimulating factor) is an important mediator of inducible haemopoiesis and inflammation, and has a critical role in the function of alveolar macrophages. Its clinical applications include the mobilization of haemopoietic progenitors, and a role as an immune stimulant and vaccine adjuvant in cancer patients. GM-CSF signals via a specific alpha receptor (GM-CSFRalpha) and the...

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PMID: 20078425
DOI: 10.1042/BJ20091745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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