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Article

Localization of a functional site on herpes simplex virus type 1 glycoprotein C involved in binding to cell surface heparan sulphate.

The Journal of general virology - 1 Apr 1994

Trybala E, Bergström T, Svennerholm B, Jeansson S, Glorioso J C, Olofsson S

Abstract excerpt

The amino acid residues critical for interaction between herpes simplex virus type 1 (HSV-1) glycoprotein C (gC-1) and cell surface heparan sulphate (HS) were localized to two separate regions within antigenic site II of this glycoprotein. These amino acids were Arg-143, Arg-145, Arg-147 and Thr-150 in one region and Gly-247 in the other. This conclusion is based on the following observations. (i) Monoclonal...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Cell Line
Epitopes
Hemagglutination Inhibition Tests
Heparan Sulfate Proteoglycans
Heparitin Sulfate
Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Molecular Sequence Data

Mutation

Neomycin

Neutralization Tests

Peptides

Polylysine

Protein Binding

Source

Identifiers

PMID: 7512117
DOI: 10.1099/0022-1317-75-4-743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7512117-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Localization of a functional site on herpes simplex virus type 1 glycoprotein C involved in binding to cell surface heparan sulphate.PMID 7512117Read ↗

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