Article
Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer.
The Journal of pathology - 1 Oct 2005
Biedermann Karin, Vogelsang Holger, Becker Ingrid, Plaschke Susanne, Siewert Jörg Rüdiger, Höfler Heinz, Keller Gisela
Abstract excerpt
Alterations of the cell adhesion molecule E-cadherin have been demonstrated in sporadic and hereditary gastric carcinomas. A cell adhesion molecule with functional similarity to E-cadherin is desmoglein 2 (Dsg2), a major component of the desmosomes. In this study, we investigated whether alterati...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cell Adhesion Molecules
- Cytoskeletal Proteins
- DNA, Neoplasm
- Desmoglein 2
- Desmogleins
- Desmoplakins
- Desmosomes
- Family Health
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Immunohistochemistry
- Male