A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy.

doi:10.1007/s10238-012-0184-7

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Article

A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy.

Clinical and experimental medicine - 1 May 2013

Garziera Marica, De Re Valli, Geremia Silvano, Seruca Raquel, Figueiredo Joana, Melo Soraia, Simões-Correia Joana, Caggiari Laura, De Zorzi Mariangela, Canzonieri Vincenzo, Cannizzaro Renato, Toffoli Giuseppe

Abstract excerpt

It is well documented that germline mutations in the E-cadherin (CDH1) gene are linked to hereditary diffuse gastric cancer (HDGC). Despite the known molecular genetic causes, most gastric cancers are sporadic and poorly investigated for susceptibility genes. We report the finding of a novel germ...

Topics

Actin Cytoskeleton
Antigens, CD
Base Sequence
Cadherins
Exons
Gastric Mucosa
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Intercellular Junctions
Italy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Models, Molecular

Mutation, Missense

Stomach Neoplasms

beta Catenin

Source

Open in PubMed

Identifiers

PMID: 22543498
DOI: 10.1007/s10238-012-0184-7

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22543498-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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