Article
A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy.
Clinical and experimental medicine - 1 May 2013
Garziera Marica, De Re Valli, Geremia Silvano, Seruca Raquel, Figueiredo Joana, Melo Soraia, Simões-Correia Joana, Caggiari Laura, De Zorzi Mariangela, Canzonieri Vincenzo, Cannizzaro Renato, Toffoli Giuseppe
Abstract excerpt
It is well documented that germline mutations in the E-cadherin (CDH1) gene are linked to hereditary diffuse gastric cancer (HDGC). Despite the known molecular genetic causes, most gastric cancers are sporadic and poorly investigated for susceptibility genes. We report the finding of a novel germline missense mutation in exon 6, c. 820 G > A (p.G274S) in one sporadic gastric cancer patient. This new variant does...
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