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Article

Loss of adenomatous polyposis coli gene function disrupts thymic development.

Nature immunology - 1 Aug 2005

Gounari Fotini, Chang Rui, Cowan Janet, Guo Zhuyan, Dose Marei, Gounaris Elias, Khazaie Khashayarsha

Abstract excerpt

Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cancer. Here we show that thymocyte-specific loss of APC deregulated beta-catenin signaling and suppressed Notch-dependent transcription. These events promoted the proliferation of cells of the double-negative 3 and 4 stages and reduced rearrangements between the variable, diversity and joining regions of the gene encoding...

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Source

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Identifiers

PMID: 16025118
DOI: 10.1038/ni1228
PMCID: PMC4662936

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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