Article
Cell surface and intracellular functions for ricin galactose binding.
The Journal of biological chemistry - 15 Jun 1992
Newton D L, Wales R, Richardson P T, Walbridge S, Saxena S K, Ackerman E J, Roberts L M, Lord J M, Youle R J
Abstract excerpt
The role of the two galactose binding sites of ricin B chain in ricin toxicity was evaluated by studying a series of ricin point mutants. Wild-type (WT) ricin and three ricin B chain point mutants having mutations in either 1) the first galactose binding domain (site 1 mutant, Met in place of Lys-40 and Gly in place of Asn-46), 2) the second galactose binding domain (site 2 mutant, Gly in place of Asn-255), or 3)...
Topics
- Animals
- Bone Marrow
- Bone Marrow Cells
- Cell Survival
- Galactose
- Lectins, C-Type
- Macrophages
- Mannose
- Mannose Receptor
- Mannose-Binding Lectins
- Mutation