Article
Mutational and structural analysis of the lectin activity in binding domain 2 of ricin B chain.
Protein engineering - 1 Oct 1994
Lehar S M, Pedersen J T, Kamath R S, Swimmer C, Goldmacher V S, Lambert J M, Blättler W A, Guild B C
Abstract excerpt
The study of the lectin binding sites of ricin B chain and of other homologous members of the small gene family that make up ricin-like molecules has revealed a number of key contact residues involved in sugar binding. In particular, on the basis of data generated by the X-ray crystallographic structure of ricin, comparisons of sequence homologies to other ricin-like molecules and substrate binding studies with...
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