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Article

A vital sugar code for ricin toxicity.

Cell research - 1 Nov 2017

Taubenschmid Jasmin, Stadlmann Johannes, Jost Markus, Klokk Tove Irene, Rillahan Cory D, Leibbrandt Andreas, Mechtler Karl, Paulson James C, Jude Julian, Zuber Johannes, Sandvig Kirsten, Elling Ulrich, Marquardt Thorsten, Thiel Christian, Koerner Christian, Penninger Josef M

Abstract excerpt

Ricin is one of the most feared bioweapons in the world due to its extreme toxicity and easy access. Since no antidote exists, it is of paramount importance to identify the pathways underlying ricin toxicity. Here, we demonstrate that the Golgi GDP-fucose transporter Slc35c1 and fucosyltransferase Fut9 are key regulators of ricin toxicity. Genetic and pharmacological inhibition of fucosylation renders diverse...

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Identifiers

PMID: 28925387
DOI: 10.1038/cr.2017.116
PMCID: PMC5674155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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