Article
Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis.
Clinical immunology (Orlando, Fla.) - 1 Jul 2004
Török Helga-Paula, Glas Jürgen, Tonenchi Laurian, Mussack Thomas, Folwaczny Christian
Abstract excerpt
Genes encoding for receptors of the innate immune system are potential candidates for susceptibility to inflammatory bowel disease, e.g., mutations in the cytosolic receptor NOD2/CARD15 were associated with Crohn's disease. Herein, two mutations of the Toll-like receptor (TLR)-4 gene (Asp299Gly and Thr399Ile) resulting in impaired lipopolysaccharide signaling, the -159C/T promotor polymorphism of the CD14 gene,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.