Article
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
Gastroenterology - 1 Jan 2003
Bonen Denise K, Ogura Yasunori, Nicolae Dan L, Inohara Naohiro, Saab Lisa, Tanabe Tsuyoshi, Chen Felicia F, Foster Simon J, Duerr Richard H, Brant Steven R, Cho Judy H, Nuñez Gabriel
Abstract excerpt
BACKGROUND & AIMS: The NOD2 variants R702W, G908R, and L1007fsinsC are strongly associated with Crohn's disease (CD) in both European and American populations, but whether this susceptibility extends to all ethnic groups remains unknown. Except for the L1007fsinsC mutation, which produces a truncated NOD2 protein, the functional activity of the major CD-associated variants G908R and R702W is unknown. METHODS:...
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