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Article

249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients.

BMC cancer - 26 Jun 2009

Nogueira Jeronimo A, Ono-Nita Suzane K, Nita Marcelo E, de Souza Marcelo M T, do Carmo Eliane P, Mello Evandro S, Scapulatempo Cristovan, Paranaguá-Vezozzo Denise C, Carrilho Flair J, Alves Venancio A F

Abstract excerpt

BACKGROUND: Ser-249 TP53 mutation (249(Ser)) is a molecular evidence for aflatoxin-related carcinogenesis in Hepatocellular Carcinoma (HCC) and it is frequent in some African and Asian regions, but it is unusual in Western countries. HBV has been claimed to add a synergic effect on genesis of this particular mutation with aflatoxin. The aim of this study was to investigate the frequency of 249(Ser) mutation in...

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Identifiers

PMID: 19558663
DOI: 10.1186/1471-2407-9-204
PMCID: PMC2708192

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Source receipt: pubmed, retrieved 7 Sept 2026.

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