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Article

TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia.

Carcinogenesis - 1 Jun 2012

Gouas Doriane A, Villar Stphanie, Ortiz-Cuaran Sandra, Legros Pénélope, Ferro Gilles, Kirk Gregory D, Lesi Olufunmilayo A, Mendy Maimuna, Bah Ebrima, Friesen Marlin D, Groopman John, Chemin Isabelle, Hainaut Pierre

Abstract excerpt

In regions with high prevalence of chronic hepatitis B virus (HBV) infection and dietary aflatoxin B(1) (AFB(1)) exposure, hepatocellular carcinomas (HCCs) often contain TP53 mutation at codon 249 (R249S). Furthermore, a C-terminal truncated HBx protein expressed from hepatocyte integrated HBV is associated with HCC development. This study evaluates the association between R249S and HBX status in relation to HCC...

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Share to Aflatoxin B1
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gambia

Share to Hepatitis B, Chronic

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Share to Viral Regulatory and Accessory Proteins

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Identifiers

PMID: 22759751
DOI: 10.1093/carcin/bgs068
PMCID: PMC3388490

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