Article
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia.
Journal of the National Cancer Institute - 19 Jan 2000
Kirk G D, Camus-Randon A M, Mendy M, Goedert J J, Merle P, Trépo C, Bréchot C, Hainaut P, Montesano R
Abstract excerpt
BACKGROUND: A selective mutation, an arginine-to-serine substitution in codon 249, of the p53 gene has been identified as a "hotspot" mutation in hepatocellular carcinoma (HCC). This mutation occurs in populations that are exposed to aflatoxins and have a high prevalence of hepatitis B virus carriers. We evaluated whether this mutation could be detected in cell-free DNA isolated from the plasma of subjects from...
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