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Article

Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometry.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2005

Lleonart Matilde E, Kirk Gregory D, Villar Stephanie, Lesi Olufunmilayo A, Dasgupta Abhijit, Goedert James J, Mendy Maimuna, Hollstein Monica C, Montesano Ruggero, Groopman John D, Hainaut Pierre, Friesen Marlin D

Abstract excerpt

A mutation in codon 249 of the TP53 gene (249(Ser)), related to aflatoxin B(1) exposure, has previously been associated with hepatocellular carcinoma risk. Using a novel internal standard plasmid, plasma concentrations of 249(Ser)-mutated DNA were quantified by electrospray ionization mass spectrometry in 89 hepatocellular carcinoma cases, 42 cirrhotic patients, and 131 nonliver diseased control subjects, all...

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Share to Aflatoxins
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Gambia

Share to Liver Cirrhosis

Share to Liver Neoplasms

Share to Spectrometry, Mass, Electrospray Ionization

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 16365016
DOI: 10.1158/1055-9965.EPI-05-0612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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