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Article

Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection.

Environmental health perspectives - 1 Nov 2011

Villar Stéphanie, Le Roux-Goglin Emilie, Gouas Doriane A, Plymoth Amelie, Ferro Gilles, Boniol Mathieu, Lereau Myriam, Bah Ebrima, Hall Andrew J, Wild Christopher P, Mendy Maimuna, Norder Helene, van der Sande Marianne, Whittle Hilton, Friesen Marlin D, Groopman John D, Hainaut Pierre

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (HBV) infection and dietary aflatoxin B1 (AFB1) exposure are etiological factors for hepatocellular carcinoma (HCC) in countries with hot, humid climates. HCC often harbors a TP53 (tumor protein p53) mutation at codon 249 (R249S). In chronic carriers, 1762T/1764A mutations in the HBV X gene are associated with increased HCC risk. Both mutations have been detected in...

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Identifiers

PMID: 21768053
DOI: 10.1289/ehp.1103539
PMCID: PMC3226502

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