Article

Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model

2017-08-04

Abstract excerpt

Whole chromosome gains or losses (aneuploidy) are a hallmark of ~70% of human tumors. Modeling the consequences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components but interpretations of these experiments are clouded by the multiple functions of these proteins. Here we used a Cre recombinase-mediated chromosome loss strategy to individually delete mouse chromosomes 9, 10, 12 or 14 i...

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Literature Corpus work: 1e1e924d-3a20-5d7e-ae87-aefc2ef5413c
DOI: 10.1101/172668

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