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Article

Traffic accidents: molecular genetic insights into the pathogenesis of the hereditary spastic paraplegias.

Pharmacology & therapeutics - 1 Jan 2006

Soderblom Cynthia, Blackstone Craig

Abstract excerpt

The hereditary spastic paraplegias (HSPs) comprise a clinically and genetically diverse group of inherited neurological disorders in which the primary manifestation is progressive spasticity and weakness of the lower limbs. The identification of over 25 genetic loci and 11 gene products for these disorders has yielded new insights into the molecular pathways involved in the pathogenesis of HSPs. In particular,...

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Identifiers

PMID: 16005518
DOI: 10.1016/j.pharmthera.2005.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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