Lipids in the Physiopathology of Hereditary Spastic Paraplegias

Abstract excerpt

Hereditary spastic paraplegias (HSP) are a group of neurodegenerative diseases sharing spasticity in lower limbs as common symptom. There is a large clinical variability in the presentation of patients, partly underlined by the large genetic heterogeneity, with more than 60 genes responsible for HSP. Despite this large heterogeneity, the proteins with known function are supposed to be involved in a limited number...

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• Endoplasmic Reticulum Stress and Disease
• Hereditary Neurological Disorders
• Lysosomal Storage Disorders Research