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Lysosome Function and Dysfunction in Hereditary Spastic Paraplegias

24 Jan 2021

Abstract excerpt

Hereditary Spastic Paraplegias (HSPs) are a genetically diverse group of inherited neurological diseases with over 80 associated gene loci. Over the last decade, research into mechanisms underlying HSPs has led to an emerging interest in lysosome dysfunction. In this review, we highlight the different classes of HSPs that have been linked to lysosome defects: (1) a subset of complex HSPs where mutations in...

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PMID: 33498913
DOI: 10.3390/brainsci11020152

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