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Article

Converging cellular themes for the hereditary spastic paraplegias.

Current opinion in neurobiology - 1 Aug 2018

Blackstone Craig

Abstract excerpt

Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci and over 60 identified genes. Studies investigating the molecular pathogenesis underlying HSPs have emphasized the...

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Identifiers

PMID: 29753924
DOI: 10.1016/j.conb.2018.04.025
PMCID: PMC6066444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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