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Article

Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms.

Experimental neurology - 1 Nov 2014

Lo Giudice Temistocle, Lombardi Federica, Santorelli Filippo Maria, Kawarai Toshitaka, Orlacchio Antonio

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition are progressive spasticity and weakness of the lower limbs. To date, 72 spastic gait disease-loci and 55 spastic paraplegia genes...

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Source

Identifiers

PMID: 24954637
DOI: 10.1016/j.expneurol.2014.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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