Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms.

Abstract excerpt

Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative disorders in which the most severely affected neurons are those of the spinal cord. These disorders are characterised clinically by progressive spasticity and weakness of the lower limbs, and pathologically by retrograde axonal degeneration of the corticospinal tracts and posterior columns. In recent years, genetic...

Topics

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• Axons
• Central Nervous System
• Genetic Predisposition to Disease
• Inheritance Patterns
• Nerve Degeneration